🔬 Science & TechnologyUPSC 1999Space & Space Technology

Which one of the following genetic diseases is sex- linked?

aRoyal haemophilia
bTay-Sachs disease
cCystic fibrosis
dHypertension
✓ Correct answer: a) Royal haemophilia
ExplanationRoyal haemophilia (also known simply as haemophilia) is a sex-linked recessive genetic disorder.It is an X-linked recessive genetic disorder characterized by impaired blood clotting due to deficiencies in clotting factors, primarily Factor VIII (Haemophilia A) or Factor IX (Haemophilia B).It primarily affects males, as the gene responsible for haemophilia is located on the X chromosome.Females can be carriers.Queen Victoria of England was a carrier of haemophilia B and passed the trait to several of her children, including her son Leopold, who died from a hemorrhage after a fall when he was30. 493

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