NEETBiology

Principles of Inheritance and Variation

59 NEET Biology previous year questions on Principles of Inheritance and Variation — options free on every question; 6 include the answer & explanation free, the rest unlock with PYQ Pass.

Q1 FREE PREVIEW
PYQ
An allele is dominant if it is expressed in:
aboth homozygous and heterozygous states.
bsecond generation.
cheterozygous combination.
dhomozygous combination.
✓ Correct answer: a) both homozygous and heterozygous states.
ExplanationAn allele is dominant if it is expressed itself in the homozygous as well as heterozygous condition.(NCERT 12th Edition (2025-26) Page No. 56)
Q2 FREE PREVIEW
PYQ
A polygenic inheritance in human beings is
askin colour
bphenylketonuria
ccolour blindness
dsickle cell anaemia
✓ Correct answer: a) skin colour
ExplanationThe correct answer is A. skin colour.Explanation: Skin color in humans is determined by the interaction of multiple genes, not just a single gene pair.This is known as polygenic inheritance, where several genes contribute to a single trait.
Q3 FREE PREVIEW
PYQ
Sex is determined in human beings
aBy ovum
bAt time of fertilisation
c40 days after fertilisation
dSeventh to eight week when genitals differentiate in fetus.
✓ Correct answer: b) At time of fertilisation
ExplanationThe sex of a human baby is genetically determined at the exact moment of fertilization (conception), when the sperm and the egg fuse.The egg (ovum) always carries an X sex chromosome.The sperm carries either an X or a Y sex chromosome.The combination at fertilization dictates the genetic sex:If an X-carrying sperm fertilizes the egg, the zygote is XX (female).If a Y-carrying sperm fertilizes the egg, the zygote is XY (male).While the physical differentiation of genitals occurs much later in fetal development (around the 7th to 8th week), the underlying genetic blueprint for sex is set immediately at fertilization.
Q4 FREE PREVIEW
PYQ
The most striking example of point mutation is found in a disease called;
aDown's syndrome.
bSickle cell anaemia.
cThalassaemia.
dKlinefelter's syndrome.
✓ Correct answer: b) Sickle cell anaemia.
ExplanationA) Down's syndrome Not due to point mutation.It is caused by trisomy of chromosome 21 (a chromosomal abnormality).B) Sickle cell anaemia Correct — It is the most striking example of point mutation.A single base substitution (A → T) in the gene coding for the β-globin chain of haemoglobin.This changes glutamic acid to valine at the 6th position.C) Thalassaemia Caused by mutations or deletions in the genes controlling haemoglobin production, but not typically a simple point mutation.
Q5 FREE PREVIEW
PYQ
Genetic identity of a human male is determined by
asex-chromosome
bcell organelles
cautosome
dnucleolus.
✓ Correct answer: a) sex-chromosome
ExplanationA. Sex-chromosome ✅ Correct.The presence of a Y-chromosome determines the male genetic identity in humans.Males: XY, Females: XX.B. Cell organelles ❌ Organelles like mitochondria, ER, etc., are present in all cells and do not determine sex.C. Autosome ❌ Autosomes are chromosomes that do not determine sex (humans have 22 pairs of them).D. Nucleolus ❌ It is a structure inside the nucleus involved in ribosome production, not related to genetic sex identity. ✅ Correct Answer: A. sex-chromosome
Q6 FREE PREVIEW
PYQ
Which one of the following conditions of the zygotic cell would lead to the birth of a normal human female child?
aTwo X chromosomes
bOnly one Y chromosome
cOnly one X chromosome
dOne X and one Y chromosome
✓ Correct answer: a) Two X chromosomes
ExplanationThe correct answer is Option A: Two X chromosomes.In humans, sex determination depends on the combination of sex chromosomes present in the zygote.A normal human female has two X chromosomes (XX).This condition arises when an X-bearing sperm fertilizes an X-bearing ovum.The presence of two X chromosomes ensures normal female development, including proper formation of reproductive organs and secondary sexual characters.Option B (only one Y chromosome) is not viable, as at least one X chromosome is essential for survival.Option C (only one X chromosome) results in Turner syndrome (XO), which is not a normal female condition.Option D (one X and one Y chromosome) produces a normal male child (XY).Therefore, a zygotic cell with two X chromosomes leads to the birth of a normal human female child.
Q7
PYQ
A gene showing co-dominance has:
aalleles tightly linked on the same chromosome.
balleles that is recessive to each other.
cboth alleles independently expressed in the heterozygote.
done allele is dominant on the other.
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Q8
PYQ
Which one from those given below is the period for Mendel's hybridisation experiments?
a1840-1850
b1857-1869
c1870-1877
d1856-1863
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Q9
PYQ
The genotypes of a husband and wife are and i respectively. Among the blood types of their children, how many different genotypes and phenotypes are possible?
a3 genotypes; 4 phenotypes
b4 genotypes; 3 phenotypes
c4 genotypes; 4 phenotypes
d3 genotypes; 3 phenotypes
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Q10
PYQ
Which of the following occurs due to the presence of autosome linked dominant trait? [NEET 2022]
aThalassemia
bSickle cell anaemia
cMyotonic dystrophy
dHaemophilia
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Q11
PYQ
Given below are two statements: Statement I: Mendel studied seven pairs of contrasting traits in pea plants and proposed the Laws of Inheritance. Statement II: Seven characters examined by Mendel in his experiment on pea plants were seed shape and colour, flower colour, pod shape and colour, flower position, and stem height. In light of the above statements, choose the most appropriate answer from the options given below: [NEET 2022]
aStatement I is incorrect but Statement II is correct.
bBoth Statement I and Statement II are correct.
cBoth Statement I and Statement II are incorrect.
dStatement I is correct but Statement II is incorrect.
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Q12
PYQ
Given below are two statements: Statement I : Failure of segregation of chromatids during cell cycle resulting in the gain or loss of whole set of chromosome in an organism is known as aneuploidy. Statement II : Failure of cytokinesis after anaphase stage of cell division results in the gain or loss of a chromosome is called polyploidy. In the light of the above statements, choose the most appropriate answer from the options given below: [Re-NEET 2024]
aStatement I is true but Statement II is false.
bStatement I is false but Statement II is true.
cBoth Statement I and Statement II are true.
dBoth Statement I and Statement II are false.
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Q13
PYQ

Which one of the following can be explained on the basis of Mendel's Law of Dominance?
A. Out of one pair of factors one is dominant and the other is recessive.
B. Alleles do not show any expression and both the characters appear as such in \({F}_{2}\) generation.
C. Factors occur in pairs in normal diploid plants.
D. The discrete unit controlling a particular character is called factor.
E. The expression of only one of the parental characters is found in a monohybrid cross.

Choose the correct answer from the options given below:

[NEET 2024]

a

A, B, C, D and E

b

A, B and C only

c

A, C, D and E only

d

B, C and D only

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Q14
PYQ

The sixth mutant codon of beta globin gene causing polymerization of Haemoglobin and change in RBC shape is ______.

[NEET 2026]

a

CAG

b

GUG

c

AUG

d

GAG

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Q15
PYQ

Given below are two statements:

Statement I: Down's syndrome is caused by the absence of one of the X-chromosomes.

Statement II: Turner's syndrome is caused by the presence of an additional copy of the chromosomes.

In the light of the above statements, choose the correct answer from the options given below:

[Re-NEET 2026]

a

Both Statement I and Statement II are correct

b

Both Statement I and Statement II are incorrect

c

Statement I is correct but Statement II is incorrect

d

Statement I is incorrect but Statement II is correct

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Q16
PYQ

Given below are two statements :
Statement I: When many alleles of a single gene govern a character, it is called polygenic inheritance.
Statement II: In Polygenic inheritance, the effect of each allele is additive.
In the light of the above statements, choose the most appropriate answer from the options given below:

[Re-NEET 2024]

a

Statement I is correct but Statement II is incorrect.

b

Statement I is incorrect but Statement II is correct.

c

Both Statement I and Statement II are correct.

d

Both Statement I and Statement II are incorrect.

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Q17
PYQ

What is the probability of having children with 'O' blood group, where both mother and father are heterozygous for 'A' and 'B' blood group, respectively?

[NEET 2026]

a

50%

b

0%

c

75%

d

25%

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Q18
PYQ

Given below are two statements:
Statement I : Failure of segregation of chromatids during cell cycle resulting in the gain or loss of whole set of chromosome in an organism is known as aneuploidy.
Statement II : Failure of cytokinesis after anaphase stage of cell division results in the gain or loss of a chromosome is called polyploidy.
In the light of the above statements, choose the most appropriate answer from the options given below:

[Re-NEET 2024]

a

Statement I is true but Statement II is false.

b

Statement I is false but Statement II is true.

c

Both Statement I and Statement II are true.

d

Both Statement I and Statement II are false.

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Q19
PYQ

When a tall pea plant with round seeds was selfed, it produced the progeny of:
(a) tall plants with round seeds and
(b) tall plants with wrinkled seeds.

Identify the genotype of the parent plant.

a

TtRr

b

TtRR

c

TTRR

d

TTRr

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Q20
PYQ

In a plant, black seed color ( BB / Bb ) is dominant over white seed color (bb). In order to find out the genotype of the black seed plant, with which of the following genotype will you cross it?

[NEET 2024]

a

BB/Bb

b

BB

c

bb

d

Bb

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Q21
PYQ

In a plant, black seed color ( BB / Bb ) is dominant over white seed color (bb). In order to find out the genotype of the black seed plant, with which of the following genotype will you cross it?

[NEET 2024]

a

BB/Bb

b

BB

c

bb

d

Bb

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Q22
PYQ

Which one of the following disorders is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule?

[NEET 2026]

a

Haemophilia

b

Thalassemia

c

Sickle-cell anaemia

d

Phenylketonuria

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Q23
PYQ

In a population of a grasshopper species, the chromosome number of some members is 23 and some other members possess 24 chromosomes. The 23 and 24 chromosome-bearing members in this species are _______ .

[NEET 2026]

a

all males

b

all females

c

females and males, respectively

d

males and females, respectively

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Q24
PYQ

Match List I with List II :

List I List II
A. Down's syndrome I. \({11}^{\text{th }}\) chromosome
B. \(\alpha\)-Thalassemia II. ' X ' chromosome
C. \(\beta\)-Thalassemia III. \({21}^{\text{st }}\) chromosome
D. Klinefelter's syndrome IV. \({16}^{\text{th }}\) chromosome
Choose the correct answer from the options given below:

[NEET 2024]

a

A-IV, B-I, C-II, D-III

b

A-I, B-II, C-III, D-IV

c

A-II, B-III, C-IV, D-I

d

A-III, B-IV, C-I, D-II

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Q25
PYQ

Genes R and Y follow independent assortment. If RRYY produce round yellow seeds and rryy produce wrinkled green seeds, what will be the phenotypic ratio of the \({\mathrm{F}}_{2}\) generation?

[NEET 2025]

a

Phenotypic ratio -9:3:3:1

b

Phenotypic ratio -9:7

c

Phenotypic ratio - 1:2:1

d

Phenotypic ratio - 3: 1

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Q26
PYQ

Which one of the following can be explained on the basis of Mendel's Law of Dominance?
A. Out of one pair of factors one is dominant and the other is recessive.
B. Alleles do not show any expression and both the characters appear as such in \({F}_{2}\) generation.
C. Factors occur in pairs in normal diploid plants.
D. The discrete unit controlling a particular character is called factor.
E. The expression of only one of the parental characters is found in a monohybrid cross.

Choose the correct answer from the options given below:

[NEET 2024]

a

A, B, C, D and E

b

A, B and C only

c

A, C, D and E only.

d

B, C and D only

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Q27
PYQ

Aneuploidy is a chromosomal disorder where chromosome number is not the exact copy of its haploid set of chromosomes, due to:
A. Substitution
B. Addition
C. Deletion
D. Translocation
E. Inversion

Choose the most appropriate answer from the options given below:

[Re-NEET 2024]

a

C and D only

b

D and E only

c

A and B only

d

B and C only

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Q28
PYQ

Given below are two statements :
Statement I: When many alleles of a single gene govern a character, it is called polygenic inheritance.
Statement II: In Polygenic inheritance, the effect of each allele is additive.
In the light of the above statements, choose the most appropriate answer from the options given below:

[Re-NEET 2024]

a

Statement I is correct but Statement II is incorrect.

b

Statement I is incorrect but Statement II is correct.

c

Both Statement I and Statement II are correct.

d

Both Statement I and Statement II are incorrect.

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Q29
PYQ

Aneuploidy is a chromosomal disorder where chromosome number is not the exact copy of its haploid set of chromosomes, due to:
A. Substitution
B. Addition
C. Deletion
D. Translocation
E. Inversion

Choose the most appropriate answer from the options given below:

[Re-NEET 2024]

a

C and D only

b

D and E only

c

A and B only

d

B and C only

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Q30
PYQ

What is the pattern of inheritance for polygenic trait?

[NEET 2025]

a

Autosomal dominant pattern

b

X-linked recessive inheritance pattern

c

Mendelian inheritance pattern

d

Non-mendelian inheritance pattern

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Q31
PYQ

Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R.

Assertion A: In an experiment, Mendel observed that the F1 progeny plants are all tall and none are dwarf.

Reason R: Stem height is a contrasting trait, with tall being dominant and dwarf being recessive.

In the light of the above statements, choose the most appropriate answer from the options given below:

[Re-NEET 2026]

a

Both A and R are correct and R is the correct explanation of A

b

Both A and R are correct but R is not the correct explanation of A

c

A is correct but R is not correct

d

A is not correct but R is correct

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Q32
PYQ

A pink flowered Snapdragon plant was crossed with a red flowered Snapdragon plant. What type of phenotype/s is/are expected in the progeny?

[NEET 2024]

a

Red, Pink as well as white flowered plants

b

Only red flowered plants

c

Red flowered as well as pink flowered plants

d

Only pink flowered plants

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Q33
PYQ

When a tall pea plant with round seeds was selfed, it produced the progeny of:
(a) tall plants with round seeds and
(b) tall plants with wrinkled seeds.

Identify the genotype of the parent plant.

[Re-NEET 2024]

a

TtRr

b

TtRR

c

TTŔR

d

TTRr

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Q34
PYQ

For a person with blood group 'O', which of the following is not a possible combination of parents' blood group genotypes?

[Re-NEET 2026]

a

Father: IA i and Mother: IBi

b

Father: IAi and Mother: IAi

c

Father: IBi and Mother: IBi

d

Father: IAIB and Mother: IAi

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Q35
PYQ

A pink flowered Snapdragon plant was crossed with a red flowered Snapdragon plant. What type of phenotype/s is/are expected in the progeny?

[NEET 2024]

a

Red, Pink as well as white flowered plants

b

Only red flowered plants

c

Red flowered as well as pink flowered plants

d

Only pink flowered plants

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Q36
PYQ

Which of the following statements are true with reference to the sex-determination in honeybees?
A. An offspring formed from the union of a sperm and an egg, develops as a female (queen or worker).
B. An unfertilized egg develops as a male by parthenogenesis.
C. A male has half the number of chromosomes than that of a female.
D. Males produce sperms by meiosis.
E. Honeybees have a haplodiploid sex-determination system.
Choose the correct answer from the options given below:

[NEET 2026]

a

B, C, D and E only

b

A, B, C and D only

c

A, B, D and E only

d

A, B, C and E only

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Q37
PYQ

The best example for pleiotropy is

[Re-NEET 2020]

a

Phenylketonuria

b

Colour Blindness

c

ABO Blood group

d

Skin colour

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Q38
PYQ

Chromosomal theory of inheritance was proposed by

a

Bateson and Punnett

b

T.H. Morgan

c

Watson and Crick

d

Sutton and Boveri

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Q39
PYQ

How many true breeding pea plant varieties did Mendel select as pairs, which were similar except in one character with contrasting traits?

a

2

b

14

c

8

d

4

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Q40
PYQ

Experimental verification of the chromosomal theory of inheritance was done by

[NEET 2020]

a

Mendel

b

Sutton

c

Boveri

d

Morgan

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Q41
PYQ

Which of the following statements are correct about Klinefelter's Syndrome?
A. This disorder was first described by Langdon Down (1866).
B. Such an individual has overall masculine development. However, the feminine development is also expressed.
C. The affected individual is short statured.
D. Physical, psychomotor and mental development is retarded.
E. Such individuals are sterile.

Choose the correct answer from the options given below:

[NEET 2023]

a

C and D only

b

B and E only

c

A and E only

d

A and B only

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Q42
PYQ

Broad palm with single palm crease is visible in a person suffering from

[NEET 2023]

a

Turner's syndrome

b

Klinefelter's syndrome

c

Thalassemia

d

Down's syndrome

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Q43
PYQ

Identify the wrong statement with reference to the gene \( I \) that controls ABO blood groups.

[NEET 2020]

a

The gene \( (I) \) has three alleles.

b

A person will have only two of the three alleles.

c

When \( I^{\mathrm{A}} \) and \( I^{\mathrm{B}} \) are present together, they express same type of sugar.

d

Allele \( i \) does not produce any sugar.

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Q44
PYQ

The production for gametes by the parents, formation of zygotes, the \(\mathrm{F}_1\) and \(\mathrm{F}_2\) plants, can be understood from a diagram called

a

Punch square

b

Punnett square

c

Net square

d

Bullet square

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Q45
PYQ

The number of contrasting characters studied by Mendel for his experiments was

a

4

b

2

c

7

d

14

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Q46
PYQ

The best example for pleiotropy is

a

Phenylketonuria

b

Colour Blindness

c

ABO Blood group

d

Skin colour

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Q47
PYQ

The phenomenon of pleiotropism refers to

a

more than two genes affecting a single character.

b

presence of several alleles of a single genc controlling a single crossover.

c

presence of two alleles, each of the two genes controlling a single trait.

d

a single gene affecting multiple phenotypic expression.

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Q48
PYQ

The number of contrasting characters studied by Mendel for his experiments was:

[Re-NEET 2020]

a

4

b

2

c

7

d

14

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Q49
PYQ

The production of gametes by parents, formation of zygote, the \( f_{1} \) and \( f_{2} \) plants can be understood from a diagram called:

[NEET 2021]

a

Punnett square

b

Net square

c

Bullet square

d

Punch square

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Q50
PYQ

In a cross between a male and female, both heterozygous for sickle cell anaemia gene, what percentage of the progeny will be diseased?

[NEET 2021]

a

\( 100 \% \)

b

\( 50 \% \)

c

\( 75 \% \)

d

\( 25 \% \)

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Q51
PYQ

Identify the wrong statement with reference to the gene ' \(I\) ' that controls ABO blood groups

a

A person will have only two of the three alleles.

b

When \(I^A\) and \(I^B\) are present together, they express own type of sugar.

c

Allele ' \(i\) ' does not produce any sugar

d

The gene \(I\) has three alleles.

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Q52
PYQ

Experimental verification of the chromosomal theory of inheritance was done by

a

Mendel

b

Sutton

c

Boveri

d

Morgan

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Q53
PYQ

Match List-I with List-II :

List-I List-II
(A) Down's syndrome (I) 11th chromosome
(B) \(\alpha\)-Thalassemia (II) 'X ' chromosome
(C) \(\beta -\)Thalassemia (III) 21st chromosome
(D) Klinefelter's syndrome (IV) 16th chromosome

Choose the correct answer from the options given below:

a

A-IV, B-I, C-II, D-III

b

A-I, B-II, C-III, D-IV

c

A-II, B-III, C-IV, D-I

d

A-III, B-IV, C-I, D-II

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Q54
PYQ

Frequency of recombination between gene pairs on same chromosome as a measure of the distance between genes to map their position on chromosome, was used for the first time by

a

Sutton and Boveri

b

Alfred Sturtevant

c

Henking

d

Thomas Hunt Morgan

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Q55
PYQ

Select the correct match.

a

Haemophilia - Y linked

b

Phenylketonuria - Autosomal dominant trait

c

Sickle cell anaemia - Autosomal recessive trait,chromosome 11

d

Thalassemia - X linked

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Q56
PYQ

Match List-I with List-II.

List-I

List-II

(A)

Pod shape

(I)

Axial

(B)

Flower colour

(II)

White

(C)

Flower position

(III)

Constricted

(D)

Pod colour

(IV)

Yellow

Choose the correct answer from the options given below:

a

A-II, B-III, C-IV, D-I

b

A-III, B-II, C-I, D-IV

c

A-IV, B-II, C-I, D-III

d

A-II, B-IV, C-III, D-I

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Q57
PYQ

Frequency of recombination between gene pairs on same chromosome as a measure of the distance between genes to map their position on chromosome, was used for the first time by

[NEET 2023]

a

Sutton and Boveri

b

Alfred Sturtevant

c

Henking

d

Thomas Hunt Morgan

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Q58
PYQ

The phenomenon of pleiotropism refers to

[NEET 2023]

a

presence of two alleles, each of the two genes controlling a single trait.

b

a single gene affecting multiple phenotypic expression.

c

more than two genes affecting a single character.

d

presence of several alleles of a single gene controlling a single crossover.

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Q59
PYQ

Chromosomal theory of inheritance was proposed by

[Re-NEET 2020]

a

Bateson and Punnet

b

T.H. Morgan

c

Watson and Crick

d

Sutton and Boveri

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